Anrukinzumab

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Inn Name
Usan NameAnrukinzumab
Lab CodesIMA-638, PF-05230917
Chemical NameImmunoglobulin G1, anti-(human interleukin-13) humanized mouse monoclonal γ1 heavy chain 235L>A, 238G>A (221-218')-disulfide with humanized mouse monoclonal κ light chain (227-227'':230-230'')-bisdisulfide dimer
Alternate NameImmunoglobulin G1, anti-(human interleukin 13) (human-mouse heavy chain), disulfide with human-mouse κ-chain, dimer
SequenceA chain
EVQLVESGGG LVQPGGSLRL SCAASGFTFI SYAMSWVRQA PGKGLEWVAS
ISSGGNTYYP DSVKGRFTIS RDNAKNSLYL QMNSLRAEDT AVYYCARLDG
YYFGFAYWGQ GTLVTVSSAS TKGPSVFPLA PSSKSTSGGT AALGCLVKDY
FPEPVTVSWN SGALTSGVHT FPAVLQSSGL YSLSSVVTVP SSSLGTQTYI
CNVNHKPSNT KVDKKVEPKS CDKTHTCPPC PAPEALGAPS VFLFPPKPKD
TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST
YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY
TLPPSREEMT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD
SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK
B chain
EVQLVESGGG LVQPGGSLRL SCAASGFTFI SYAMSWVRQA PGKGLEWVAS
ISSGGNTYYP DSVKGRFTIS RDNAKNSLYL QMNSLRAEDT AVYYCARLDG
YYFGFAYWGQ GTLVTVSSAS TKGPSVFPLA PSSKSTSGGT AALGCLVKDY
FPEPVTVSWN SGALTSGVHT FPAVLQSSGL YSLSSVVTVP SSSLGTQTYI
CNVNHKPSNT KVDKKVEPKS CDKTHTCPPC PAPEALGAPS VFLFPPKPKD
TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST
YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY
TLPPSREEMT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD
SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK
C chain
DIQMTQSPSS LSASVGDRVT ITCKASESVD NYGKSLMHWY QQKPGKAPKL
LIYRASNLES GVPSRFSGSG SGTDFTLTIS SLQPEDFATY YCQQSNEDPW
TFGGGTKVEI KRTVAAPSVF IFPPSDEQLK SGTASVVCLL NNFYPREAKV
QWKVDNALQS GNSQESVTEQ DSKDSTYSLS STLTLSKADY EKHKVYACEV
THQGLSSPVT KSFNRGEC
(D chain)
DIQMTQSPSS LSASVGDRVT ITCKASESVD NYGKSLMHWY QQKPGKAPKL
LIYRASNLES GVPSRFSGSG SGTDFTLTIS SLQPEDFATY YCQQSNEDPW
TFGGGTKVEI KRTVAAPSVF IFPPSDEQLK SGTASVVCLL NNFYPREAKV
QWKVDNALQS GNSQESVTEQ DSKDSTYSLS STLTLSKADY EKHKVYACEV
THQGLSSPVT KSFNRGEC

Disulfide bridge: A22-A95, A145-A201, A221-C218, A227-B227, A230-B230, A262-A322, A368-A426, B22-B95, B145-B201, B221-D218, B262-B322, B368-B426, C23-C92, C138-C198, D23-D92, D138-D198
Chemical StructureAnrukinzumab.png
Molecular FormulaC6452H9954N1714O2024S46
Cas Registry Number910649-32-0
New Molecular EntityYes
OriginatorWyeth
DeveloperPfizer
Mechanism Of ActionInterleukin 13 inhibitor
Who Atc CodesA07E (Intestinal Antiinflammatory Agents)
R03 (Drugs for Obstructive Airway Diseases)
Ephmra CodesA7E (Intestinal Anti-Inflammatory Agents)
R3 (Anti-Asthma and COPD Products)
IndicationAsthma, Ulcerative Colitis

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