Dezamizumab

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Inn NameDezamizumab
Lab CodesGSK-2398852
Chemical NameImmunoglobulin G1-kappa, anti-[Homo sapiens APCS (amyloid P component serum, serum amyloid P component, SAP, pentraxin-2, PTX2)], humanized monoclonal antibody; gamma1 heavy chain (1-452) [humanized VH (Homo sapiens IGHV1-69*02 (85.70%) -(IGHD)-IGHJ5*01) [8.8.15] (1-122) -Homo sapiens IGHG1*01, G1m17,1 (CH1 (123-220), hinge (221-235),CH2 (236-345), CH3 (346- 450), CHS (451-452)) (123-452)], (225-214')-disulfide with kappa light chain (1’-214’) [humanized V-KAPPA (Homo sapiens IGKV1-39*01 (85.30%) -IGKJ2*01) [6.3.9] (1'-107')-Homo sapiens IGKC*01, Km3 (108'-214')]; dimer (231-231":234-234")-bisdisulfide
SequenceHeavy chain
QVQLVQSGAE VKKPGSSVKV SCKASGFTFA TYNMHWVRQA PGQGLEWMGY 50
IYPGDGNANY NQQFKGRVTI TADKSTSTAY MELSSLRSED TAVYYCARGD 100
FDYDGGYYFD SWGQGTLVTV SSASTKGPSV FPLAPSSKST SGGTAALGCL 150
VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV VTVPSSSLGT 200
QTYICNVNHK PSNTKVDKKV EPKSCDKTHT CPPCPAPELL GGPSVFLFPP 250
KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ 300
YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE 350
PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP 400
PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP 450
GK 452

Light chain
DIQMTQSPSS LSASVGDRVT ITCRASENIY SYLAWYQQKP GKAPKLLIHN 50
AKTLAEGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCQH HYGAPLTFGQ 100
GTKLEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV 150
DNALQSGNSQ ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG 200
LSSPVTKSFN RGEC 214

Disulfide bridges location
Intra-H (C23-C104) 22-96 149-205 266-326 372-430
22''-96'' 149''-205'' 266''-326'' 372''-430''
Intra-L (C23-C104) 23'-88' 134'-194'
23'''-88''' 134'''-194'''
Inter-H-L (h 5-CL 126) 225-214' 225''-214'''
Inter-H-H (h 11, h 14) 231-231'' 234-234''

N-glycosylation sites
H CH2 N84.4:
302, 302''
Fucosylated complex bi-antennary CHO-type glycans
Chemical StructureDezamizumab.png
Orphan Drug StatusYes
Orphan IndicationAmyloidosis
New Molecular EntityYes
OriginatorPentraxin Therapeutics
DeveloperGlaxoSmithKline
Mechanism Of ActionSerum amyloid P component inhibitor
Who Atc CodesA16A (Other Alimentary Tract and Metabolism Products)
Ephmra CodesA16A (Other Alimentary Tract and Metabolism Products)
IndicationAmyloidosis

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