Eptinezumab

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ALD403 is an investigational monoclonal antibody targeted to calcitonin gene-related peptide, or CGRP, for migraine prevention. CGRP is a small protein involved in the transmission of and heightened sensitivity to pain experienced in migraine.

Inn NameEptinezumab
Lab CodesALD-403
Chemical NameImmunoglobulin G1-kappa, anti-[Homo sapiens CALCA (calcitonin related polypeptide alpha) calcitonin gene-related peptide 1, CGRP1, 83-119 and Homo sapiens CALCB (calcitonin related polypeptide beta) calcitonin gene-related peptide 2, CGRP2, 82-118], humanized monoclonal antibody; gamma1 heavy chain (1-441) [humanized VH (Homo sapiens IGHV3-66*01 (81.40%) (IGHD)-IGHJ3*02) [8.7.5] (1-111) - Homo sapiens IGHG1*03 (CH1 K119>A (156) (112-209), hinge (210-224), CH2 N84.4>A (291) (225-334), CH3 (335- 439), CHS (440-441)) (112-441)], (214 219')-disulfide with kappa light chain (1’-219’) [humanized V-KAPPA (Homo sapiens IGKV1-27*01 (86.20%) -IGKJ4*01) [8.3.13] (1'-112') - Homo sapiens IGKC*01, Km3 (113'-219')]; dimer (220 220":223-223")-bisdisulfide
SequenceHeavy chain
EVQLVESGGG LVQPGGSLRL SCAVSGIDLS GYYMNWVRQA PGKGLEWVGV 50
IGINGATYYA SWAKGRFTIS RDNSKTTVYL QMNSLRAEDT AVYFCARGDI 100
WGQGTLVTVS SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV 150
SWNSGALTSG VHTFPAVLQS SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP 200
SNTKVDARVE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT 250
PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY ASTYRVVSVL 300
TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRE 350
EMTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL 400
YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG K 441

Light chain
QVLTQSPSSL SASVGDRVTI NCQASQSVYH NTYLAWYQQK PGKVPKQLIY 50
DASTLASGVP SRFSGSGSGT DFTLTISSLQ PEDVATYYCL GSYDCTNGDC 100
FVFGGGTKVE IKRTVAAPSV FIFPPS DEQL KSGTASVVCL LNNFYPREAK 150
VQWKVDNALQ SGNSQESVTE QDSKDSTYSL SSTLTLSKAD YEKHKVYACE 200
VTHQGLSSPV TKSFNRGEC 219

Disulfide bridges location
Intra-H (C23-C104) 22-95 138-194 255-315 361-419
22''-95'' 138''-194'' 255''-315'' 361''-419''
Intra-L (C23-C104) 22'-89' 139'-199' Intra-L 95'-100'
22'''-89''' 139'''-199''' (C110-C115) 95'''-100'''
Inter-H-L (h 5-CL 126) 214-219' 214''-219'''
Inter-H-H (h 11, h 14) 220-220'' 223-223''

N-glycosylation sites
H CH2 N84.4>A (291, 291''):
No N-glycosylation sites

Chemical StructureEptinezumab.png
Cas Registry Number1644539-04-7
New Molecular EntityYes
OriginatorAlder Biopharmaceuticals
Mechanism Of ActionCalcitonin gene-related peptide antagonist
Who Atc CodesN02C (Antimigraine Preparations)
Ephmra CodesN2C (Anti-Migraine Preparations)
IndicationMigraine

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