Lupartumab

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Inn NameLupartumab
Lab CodesBAY-1112623
Chemical NameImmunoglobulin G1-lambda1, anti-[Homo sapiens LYPD3 (Ly6/PLAUR domain containing 3, GPI-anchored cellsurface protein C4.4a, C4.4A)], Homo sapiens monoclonal antibody; gamma1 heavy chain (1-446) [Homo sapiens VH (IGHV3- 48*03 (92.90%) -(IGHD) -IGHJ4*01) [8.8.10](1-117) - IGHG1*01, Gm17,1 (CH1 (118-215), hinge (216-230), CH2 (231-340), CH3 (341-445), CHS K>del (446)) (118-446)], (220-216')-disulfide with lambda1 light chain (1'-217') [Homo sapiens V-LAMBDA (IGLV1-47*01 (87.90%) - IGLJ2*01) [9.3.11] (1'-111') -IGLC2*01 (112'-217')]; dimer (226 226'':229-229'')-bisdisulfide
Alternate NameImmunoglobulin G1, anti-(human gpi-anchored cell surface-associated protein C4.4a) (human monoclonal BAY 1112623 heavy chain), disulfide with human monoclonal BAY 1112623 light chain, dimer
SequenceHeavy chain
EVQLLESGGG LVQPGGSLRL SCAASGFTFS NAWMSWVRQA PGKGLEWVSY 50
ISSSGSTIYY ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCAREG 100
LWAFDYWGQG TLVTVSSAST KGPSVFPLAP SSKSTSGGTA ALGCLVKDYF 150
PEPVTVSWNS GALTSGVHTF PAVLQSSGLY SLSSVVTVPS SSLGTQTYIC 200
NVNHKPSNTK VDKKVEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT 250
LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY 300
RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT 350
LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS 400
DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPG 446

Light chain
ESVLTQPPSV SGAPGQRVTI SCTGSSSNIG AGYVVHWYQQ LPGTAPKLLI 50
YDNNKRPSGV PDRFSGSKSG TSASLAISGL RSEDEADYYC AAWDDRLNGP 100
VFGGGTKLTV LGQPKAAPSV TLFPPSSEEL QANKATLVCL ISDFYPGAVT 150
VAWKADSSPV KAGVETTTPS KQSNNKYAAS SYLSLTPEQW KSHRSYSCQV 200
THEGSTVEKT VAPTECS 217

Disulfide bridges location
Intra-H (C23-C104) 22-96 144-200 261-321 367-425
22''-96'' 144''-200'' 261''-321'' 367''-425''
Intra-L (C23-C104) 22'-90' 139'-198'
22'''-90''' 139'''-198'''
Inter-H-L (h 5-CL 126) 220-216' 220''-216'''
Inter-H-H (h 11, h 14) 226-226' 229-229''

N-glycosylation sites
H CH2 N84.4:
297, 297''
Fucosylated complex bi-antennary CHO-type glycans

Chemical StructureLupartumab.png
Cas Registry Number1640971-88-5
OriginatorBayer HealthCare
Who Atc CodesL01 (Antineoplastic Agents)
Ephmra CodesL1 (Antineoplastics)
IndicationNeoplasms

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