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AMG 899 is a small molecule cholesteryl ester transfer protein (CETP) inhibitor. It is being investigated for the treatment of dyslipidemia.

Inn NameObicetrapib
Lab CodesAMG-899, TA-8995, DEZ-001
Chemical Name4-{[2-({[3,5-bis(trifluoromethyl)phenyl]methyl}[(2R,4S)-1-(ethoxycarbonyl)-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-4-yl]amino)pyrimidin-5-yl]oxy}butanoic acid
Chemical StructureObicetrapib.png
Molecular FormulaC32H31F9N4O5
Cas Registry Number866399-87-3
New Molecular EntityYes
DeveloperMitsubishi Tanabe Pharma Corp, Xention
Mechanism Of ActionCholesterol ester transfer protein inhibitor
Who Atc CodesC10A-X (Other lipid modifying agents)
Ephmra CodesC10A9 (All other cholesterol/triglyceride regulators)

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