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MBX-8025 is a selective agonist for the peroxisome proliferator-activated receptor delta (PPARĪ“), a nuclear receptor that regulates genes involved in lipid storage and transport (particularly in fatty acid oxidation) and insulin signaling and sensitivity.

Inn NameSeladelpar
Lab CodesMBX-8025, RWJ-800025
Chemical Name[4-({(2R)-2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl}sulfanyl)-2-methylphenoxy]acetic acid
Chemical StructureSeladelpar.png
Molecular FormulaC21H23F3O5S
Cas Registry Number851528-79-5
Orphan Drug StatusYes
Orphan IndicationHyperlipoproteinaemia type V, Hyperlipoproteinaemia type I, Hyperlipoproteinaemia type IIa
New Molecular EntityYes
DeveloperCymaBay Therapeutics
Mechanism Of ActionPeroxisome proliferation activated receptor (PPAR) delta agonist
Who Atc CodesA05 (Bile and Liver Therapy)
C10 (Lipid Modifying Agents)
Ephmra CodesA5 (Cholagogues and Hepatic Protectors)
C10 (Lipid-Regulating/Anti-Atheroma Preparations)
IndicationPrimary Biliary Cirrhosis (PBC), Hyperlipidemia, Homozygous Familial Hypercholesterolemia

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